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Pathological increases in local concentrations of ROS cause oxidative stress (102)

In addition, the Bmal1, REVERB, and ROR genes constitute a regulatory feedback loop, and Bmal1 transcription is negatively regulated by REVERB and positively regulated by ROR

Post-Inflammatory Hyperpigmentation (PIH): PIH occurs as a result of inflammation or injury to the skin caused by acne, eczema, psoriasis, or allergic reactions

doi: 10.3389/fnagi.2021.785727 Received 29 September 2021 Accepted 01 December 2021 Published 17 December 2021 Volume 13 - 2021 Edited by Gustavo Provensi, University of Florence, Italy Reviewed by Mnica Lpez-Hidalgo, National Autonomous University of Mexico, Mexico