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Changes in osteoclast activity usually result in a noticeable change in TbPf, but no significant differences were found ( p = 0.303)
Additionally, a 2025 retrospective study on chronic knee pain showed that 14 out of 16 patients reported significant relief lasting 612 months, and a 2024 pilot study on interstitial cystitis achieved symptom resolution in 10 out of 12 subjects
