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Description
The damage caused by SAP to the vascular endothelium is manifested as the release of inflammatory mediators and leukocyte adhesion, increased vascular permeability, changes in blood flow shear stress, microthrombosis, and microcirculatory disorders

One cause can be liver stress due to your hypothyroid state, meaning it wont be doing a good job clearing out your excess B12

Kulcenty, K., Holysz, M

too little may not offer the desired therapeutic benefit
