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Description
DTT, also known as Clelands Reagent, is an unusually strong reducing agent, owing to its high conformational proprensity to form a six member ring with an internal disulfide bond. DTT is frequently used to reduce the dissulfide bonds of proteins and, more generally, to preventintramolecularand intermoleculardisulfide bonds from forming between cysteine residues of proteins
As a potent antioxidant and a natural dithiol compound, it performs a crucial role in mitochondrial bioenergetic reactions
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Glioblastoma therapy is challenging, and new approaches are needed