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Effect of the mutations on FeS cluster binding and stability Our structural analysis revealed significant differences in the orientation of the GSH thiol in both Grx classes

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An experimental plan was thus drawn up, including solvent type, extraction time and solid-liquid ratio, to assess the combined impact of these factors on GSH extraction

Since the amount and quality of leptin receptors in the hypothalamus appears to be normal in the majority of obese humans (as judged from leptin-mRNA studies), [123] it is likely that the leptin resistance in these individuals is due to a post leptin-receptor deficit, similar to the post-insulin receptor defect seen in type 2 diabetes