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The published literature attributes this to the sample pH approaching the peptides pI, to insufficient acidic pre-dissolution, or to a peptide concentration above the critical aggregation concentration

10.1007/s11064-015-1631-0 5 BenardG.KarbowskiM

In contrast, high molecular weight soluble A aggregates are more likely to induce microglial activation, resulting in neuroinflammatory responses (Figueiredo et al., 2013)

coli ) and purified them by a three-step purification strategy combining ammonium sulfate precipitation, exclusion chromatography, and ion-exchange chromatography
