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evaluated 90 patients undergoing bariatric surgery and intraoperative liver biopsy [46]

M1 and M2 represent two phenotypes in macrophages with completely opposite functions, The former is characterized by high expression of pro-inflammatory cytokines, including IL-1, IL-6, IL-12, and TNF-, while the latter predominantly produces anti-inflammatory cytokines like IL-10 and TGF- (Shapouri-Moghaddam et al., 2018)

In addition, age dependent accretion of dysfunctional mitochondria elevates stress level, which is exhibited by high levels oxidized products such as protein carbonyls and lipid peroxides 42

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