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[PubMed] [Google Scholar] 262.Shimizu T, Shimizu S, Higashi Y, et al

Increased plasma xanthine and hypoxanthine can also occur consequent to disorders of mitochondrial oxidative phosphorylation or of glycogen metabolism (77)

Glutamate acts through eight ionotropic and metabotropic receptor subtypes (mGluR1mGluR8) that have been classified into three groups: Group I receptors (mGluR1 and mGluR5) are coupled to G q proteins and phospholipase C and are involved in central sensitization and pain chronification

5.3 Therapeutic challenges Despite significant progress, several limitations restrict translation of mitochondrial-targeted therapies