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Symptoms begin before age 20.These patients have hyporeflexia, reduced proprioception and vibratory sense, muscle weakness, and spino-cerebellar ataxia

Many women feel tired due to long working hours and household responsibilities

In detail, AR is imported into and localizes to mitochondria with the help of a genuine 36-amino-acid-long mitochondrial localization signal at the N terminus and impedes mtDNA content, TFAM expression, and the expression, assembly, stability, and activity of oxidative phosphorylation (OXPHOS) (90)

Another important issue is the damage caused by cryopreservation of sperm as part of assisted reproductive technology