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133 The role of ERAD and UPR in metabolic diseases ER stress is a hallmark of metabolic diseases such as T2DM, insulin resistance, and MASLD

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HT29, HCT116, and RKO cells were grown in McCoys medium (Invitrogen)

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MGF (IGF-1Ec) is a naturally occurring splice variant of the IGF-1 gene produced locally in mechanically stressed muscle, defined by a unique E-domain peptide

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A high dose of MSM (0.4%) fits the requirement for short-term use, and a low dose (0.2%) is more suitable for long-term inclusion

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