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CRISPR/Cas9-mediated knockout of MFI2 in human melanoma cells resulted in enhanced invasiveness and significant alterations in the expression of genes associated with tumorigenic progression and metastasis [33]

In the clinical-translational setting, the fundamental importance of ketogenic metabolism for human T cells has already been demonstrated in the context of critically ill COVID-19 patients and, in particular, the improvement of T cell immune metabolism by ketone bodies has been demonstrated in compromised T cells of intensive care patients (89)

PMID 15483230

[DOI] [PubMed] [Google Scholar] 134.Mantovani G., Madeddu C., Maccio A