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doi: 10.1101/2020.09.01.278747 269
On the neurological side, the pro-inflammatory factor released by AT may have first caused ferroptosis in the vagus nerve by inhibiting of the NRF2-GPX4 pathway, resulting in disorders of the autonomic nervous system
48 These cells were subsequently reinfused into patients to evaluate their clinical efficacy and establish the safety profile of these stromal cells
In a phase III study, known as COSMIC-312 (NCT03755791), which compared cabozantinib in combination with atezolizumab to sorafenib as a first-line therapy for advanced HCC, the combination therapy significantly improved PFS [142]
