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Abbreviations DPPOS: Diabetes Prevention Program Outcomes Study GWAS: Genome-wide association study IF: Intrinsic factor MHRA: Medicines and Healthcare products Regulatory Agency PPI: Proton pump inhibitor QC: Quality control UKB: UK Biobank References Kim J, Ahn CW, Fang S, Lee HS, Park JS (2019) Association between metformin dose and vitamin B12 deficiency in patients with type 2 diabetes

97 found that isocaloric protein restriction down to 12E% over 3 months was not able to reproduce the beneficial metabolic changes induced by CR in male C57BL/6 mice, in particular the decrease in IGF-1 concentrations

Advancements in technology have indicated that lycopene extraction rate could be enhanced, thus solving the problems of higher costs of production and inadequate supply, and thus the profiles and possible pharmaceutical value have been bolstered (Deng et al., 2021)