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The recently available adjuvant therapy regimens for melanoma raise the problem of a careful distinction between severely atypical (high grade) melanocytoma and classical melanoma: conventional morphology can guide an algorithmic approach based on an antibody panel (anti-mutated BRAF, BAP1, PRAME, ALK, TRKA, MET, HRAS-WT, ROS

This case highlights critical diagnostic challenges, the limitations of conventional imaging and pathology, and the urgent need for refined surgical and molecular strategies in managing this rare malignancy

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