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Tabe Y, Jin L, Hatanaka Y, Miida T, Kornblau SM, Andreeff M , Konopleva M

Kinase drug discovery 20 years after imatinib: progress and future directions

In the Sod1 transgenic mouse model of ALS, supplementation of Akkermansia muciniphila increases the serum levels of nicotinamide and leads to improvements in motor and neurological function, suggesting that nicotinamide released from gut microbiota has a beneficial effect on ALS pathogenesis [175]

Le Gassicke J