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SIDEBAR: Interpretation of Helen's Lab Values Here is a brief explanation of what Helen's laboratory values indicate in the context of her clinical presentation, based on current rheumatology guidelines: ESR (58 mm/hour) and CRP (40 mg/dL) : The significantly elevated erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels represent an acute phase response, indicating the presence of active systemic and intraarticular inflammation (England et al., 2025

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10.1073/pnas.2011350117 77 ZhangW.DouradoD