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In the reported cases, the clinical presentation consisted of recurrent episodes of Reye-like encephalopathy, hypoketotic hypoglycemia, and/or cardiomyopathy
In rats, the CB1 activation decreases hypothalamic serotonergic activity, an important satiety signal, and induces disinhibition of GABA release to stimulate food intake (Cruz-Martinez et al., 2018)
135(5): 125562 Bleakman D, Alt A, Nisenbaum ES
