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In vivo molecular imaging of neuroinflammation in Alzheimer's disease
Cheah IK, Ong RL, Gruber J, et al
Although molecular oxygen is relatively stable, its reduction leads to the formation of reactive oxygen species (ROS), which are naturally and continuously produced as a byproduct of aerobic cellular metabolism
The 2 mg starting point from the phase 2 trial was specifically designed for this scenario, since the trial participants included people with varying levels of prior medication exposure
