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This unexpected outcome likely resulted from indirect attenuation of dopaminergic signaling due to combined PDE10A inhibition and D 2 receptor blockade from antipsychotics, producing excessive suppression of dopaminergic signals

10.1038/ng1658 [DOI] [PMC free article] [PubMed] [Google Scholar] Ohgami RS, Campagna DR, McDonald A, & Fleming MD (2006)

Apart from some mild marginal astrocytosis, they show surprisingly little evidence of reactive or inflammatory change

TB500 Fragment (1723), also known as fequesetide, is a highpurity, research-grade heptapeptide derived from the active domain of thymosin beta4 (TB4), engineered to model actin regulation, cell migration, and tissue repair in controlled experimental systems