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In addition, McGuinness et al

Relative Cell Survival Assays Cells were pre-treated with Vehicle control (0.1% DMSO) or Rucaparib (15 M) for two hours followed by treatment with various concentrations of IB-DNQ as indicated in combination with vehicle control (0.1% DMSO) or Rucaparib (15 M) for additional two hours

Therefore, a question arises: when the intracellular levels of ROS increase and exceed the compensatory limits of the cell, which of the three types of cell death will occur
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