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High dose ( 0.5 mg/kg/d) or long-term use may lead to hypoglycemia, especially in patients with diabetes or insulin resistance
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Neuronal precursor survival Zn also plays a role in the survival of neuronal precursor cells, as it regulates the expression of both pro-survival pathways, like the ERK, Ak strain transforming (Akt), and nuclear factor (NF)-kB pathways, and pro-apoptotic cascades, such as the Jun N-terminal kinase (JNK) and p53 pathways
