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Melittin binds to p50 with high affinity (Kd = 1.2 108 M)

Cascione et al., Subcapsular sinus macrophages promote Melanoma Metastasis to the Sentinel Lymph nodes via an IL1STAT3 Axis
26 Within the TME, cancer cells can establish an immunosuppressive metabolic microenvironment by depriving immune cells of vital metabolites such as glucose and oxygen while also elevating the levels of mediators such as lactate and adenosine that limit the function of immune cells

1994;140 (Pt 10):264956