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Functional siRNA delivery by extracellular vesicle-liposome hybrid nanoparticles

This contrasted with a short and weak blood pressure rise and a 75% death rate before the end of the 45 minute experimental period in the control group

Notably, the wt AWA dynamical features were restored: When facing a stimulus gradient, the pulsatile activity was reestablished (Fig 3AD and Appendix Fig S3D), and the amplitude of these pulses was reduced to wt levels (Fig 3E)

Prior studies on MDA-MB-231 cells required combination treatment of 3 M -lapachone with 15 M Rucaparib for cell killing whereas 0.1 M IB-DNQ was sufficient for TNBC cell killing in combination with 15 M Rucaparib in our long-term survival assays (12)