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Data suggest that there is an increased incidence of congenital malformations associated with the use of valproate by women with seizure disorders during pregnancy when compared to the incidence in women with seizure disorders who do not use antiepileptic drugs during pregnancy, the incidence in women with seizure disorders who use other antiepileptic drugs, and the background incidence for the general population

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Epub 2020 Aug 15

People with severe ME/CFS are usually housebound (11) and have a functional capacity ranging from 5% to 15% of normal functioning (39)