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Preclinically, hydroxocobalamin has been tested in dogs given a lethal dose of cyanide and subsequently assigned to 150 mg/kg, 75 mg/kg, or vehicle (0.9% saline) drug treatments
The extrinsic pathway involves the activation of a protease cascade intitated by the activation of caspase 8 through the action of death receptors and their ligands, for example, FasL, and tumor necrosis factor- (181)
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A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks
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