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The bifunctional enzyme inositol-requiring enzyme 1 (IRE1) exhibits both protein kinase and site-specific endoribonuclease activities, enabling XBP1 mRNA processing and targeted decay of ER-associated transcripts via Regulated IRE1-Dependent Decay (RIDD) ( In AT, obesity induces pronounced ER stress that fundamentally disrupts metabolic homeostasis through multiple tissue-specific mechanisms (102)

Crecimiento un 50% ms rpido: El tiempo necesario para que los injertos recin transplantados comiencen a crecer se redujo aproximadamente a la mitad

B Biointerfaces 224 , 113229 (2023)

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