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The endothermicity calculated for the dicarboxylate is considerably lower than for the di-hydroxyl species (2-OH-SS) (32.9 versus 47.9 kJ mol 1 ), but comparable to the calculated value for dimethyldisulfide (31.6 kJ mol 1 ), which is neutral and does not include the strongly electron-withdrawing OH groups

doi: 10.1016/j.nbd.2018.08.013

70 HP 130 AOD-9604 HGH Fragment 176-191 Lipolytic ALIASES AOD-9604, AOD9604, hGH(176-191), Tyr-hGH(177-191) CLASS Synthetic growth-hormone C-terminal fragment lipolytic candidate FORMULA CHNOS SEQUENCE 16-residue fragment corresponding to hGH(177-191) with N-terminal Tyrosine addition HALF-LIFE Short (minutes) plasma ROUTES Subcutaneous (Phase 2 obesity) Oral (food-supplement contexts in some jurisdictions) MECHANISM OF ACTION Synthetic 15-amino-acid fragment of human growth hormone (residues 176-191)

Ashino T, OhkuboMorita H, Yamamoto M, Yoshida T, Numazawa S