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In laboratory studies, inhibiting NNMT has been investigated for effects on cellular NAD+ levels and adipocyte (fat-cell) metabolism

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Reportedly, NF-B activation has anti- oxidant and pro-oxidant roles, the former involves the suppression of ROS accumulation, autophagy promotion, Inhibition of JNK activation and increased anti-oxidant targets whereas the pro-oxidant role includes the induction of pro-oxidation genes
