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The formulation and excipients in B12 supplements often play a significant role
Repeat every 23 months in severely deficient areas, or every 56 months where deficiency is mild

The breakdown of faulty red blood cells can also cause jaundice

The inhibitory effects of chronic exposure of vitamin B12 on glutamate-induced neurotoxicity were determined in cell culture, probably by altering the membrane properties through S-adenosylmethionine (SAM)-mediated methylation [26, 27]
