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Although this goes beyond the scope of this review, it is worth mentioning that other factors can contribute to limit levodopa absorption in PD patients

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Further, male rats had increased mortality, while surviving females displayed a significant decrease in serum IGF-1 and nearly a doubling of infarct volume and sensorimotor deficits ( In addition to disruption of circadian rhythms by repeated phase shifts (jet lag), foundational science research has examined the role of circadian disruption by light at night in stroke outcome