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High-dose supplementationparticularly intramuscular injections that can deliver 1,000 micrograms or morecreates substantially elevated serum B12 levels compared to dietary intake, which may more readily trigger these bacterial changes, though comparative studies between different forms are limited
Researchers became interested when preclinical studies demonstrated that adding glucagon receptor agonism to incretin-based therapy produced metabolic effects that exceeded those of GLP-1 or GIP activation aloneparticularly in energy expenditure and hepatic lipid metabolism
