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Collectively, the physicochemical-optimized nanoparticles can be designed as a highly promising platform for effective anti-Alzheimer's drug delivery, in which, within this criteria window, nanoparticles exhibit (i) prolong systemic circulation time, reducing rapid clearance by immune system and enhance passive targeting due to the pathology of AD (Snchez-Lpez et al., 2018

H., et al., Tumor Biomarkers for Diagnosis, Prognosis and Targeted Therapy, Signal Transduction And Targeted Therapy 9, no

The flora with increased abundance includes Lactobacillus salivarius , Staphylococcus , Corynebacterium , Bacteroides fragilis , Ruminococcus gnavus , Veillonella parvula , Pseudobutyrivibrio , Escherichia/Shigella , and Streptococcus parasanguinis (201, 203, 204)

Zinc has many functions, the most known is the bodys defense