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The methylation of harmful estrogens 4OH E1 and E2 inactivates and effectively neutralizes the volatile 4OH molecule

The thiamine-induced increases in contractions of the intestine smooth muscle and peristalsis, observed in a number of independent in vitro experiments on muscle strips of gastrointestinal tract (207, 219222), support the action of thiamine on ACh signaling in ENS in the absence of central regulation (236)

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