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Higashijima, Y., Tanaka, T., Yamaguchi, J., Tanaka, S

Thus, in the course of aging various potentially pathogenic mechanisms, including the increase in oxidative damage, could on the one hand influence the quality of aging and on the other favour the onset and evolution of a definite neurodegenerative disease

On top of the role of NAD + as a direct substrate for the TCA and ETC, much of the influence of NAD + on mitochondrial homeostasis is through the NAD + -consuming enzymes sirtuins

Studies indicate that hypoxia can promote the viability, proliferation, and migration of bone marrow-derived MSCs (BMSCs) (Tsai et al., 2011