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De Angelis et al

(2022) study [146] to support the applicant's statement that in patients with IPF, HP 129 Xe MRI can predict disease progression in patient population where fibrosis is not detectable by traditional CT, as the study authors suggested that findings need to be verified in a longitudinal multicenter study with more rigorous testing of the repeatability of the MRI-based measurements of gas exchange and ventilation in a larger sample of participants with IPF

[DOI] [PMC free article] [PubMed] [Google Scholar] 170.Nakamura A., Hasegawa M., Minami K., Kanbara T., Tomii T., Nishiyori A., Narita M., Suzuki T., Kato A

Moreover, SIRT -1 reduces ferroptosis by activating autophagy ( N-acetylcysteine is the cornerstone treatment for hepatotoxicity following APAP overdose