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In presence of galactose in the plates, GLYIKO cells could not grow well even in 1 mM MG concentration whereas all other cells showed a steady growth (Fig

Finally, we discuss emerging strategies to interrogate and modulate this circuit using integrated omics, CRISPR-based screening, and pharmacological approaches, emphasizing the need for context-aware and temporally controlled metabolic interventions to enhance T cellbased immunotherapies in solid tumors