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Preliminary kinetic studies indicated that equilibrium binding was reached by 40 min of incubation at 37C

Mulligan T, Frick MF, Zuraw QC, et al

Models in vivo, 1D228 showed robust anti-tumor effect on gastric and liver tumor growth with 94.8% and 93.4% of the TGI, respectively, comparing 67.61% and 63.9% of Tepotinib

The agency typically issues a final decision four to nine months after the comment period closes, putting an answer somewhere in the November 2026 to March 2027 window
