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In this respect, an interesting study conducted on immortalized human microglia cells (CVCL_5G94) highlighted how ATRAs can increase the heat shock protein 90 (Hsp90) expression on the surface of these cells, causing an increase in the amount of endocytosed and consequently eliminated tau protein (25)
Inhibiting de Novo ceramide synthesis restores mitochondrial and protein homeostasis in muscle aging
However, its effects on LVMI and markers of diastolic function are inconclusive
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