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It contributes to: Cellular antioxidant defense Redox signaling and enzyme regulation Normal metabolism of certain drugs and environmental compounds Recycling of other antioxidant systems Immune-cell function Mitochondrial protection Protein structure and cellular repair Glutathione is not a magical cleanse

Unravelling the contribution of melanoidins to the antioxidant activity of coffee brew

TGR inhibitors do not react covalently with GSH, selenocysteine, or TGR, and inhibition of TGR is reversible To evaluate stability of the TGR inhibitors in the presence of GSH and selenocysteine, compound 2 and a known covalent inhibitor of TGR, TRi-1 20,45 , were incubated with GSH or the N-Boc protected methyl ester of selenocysteine, and the reaction mixtures were analyzed by LCMS (Supplementary Figs