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The downregulation of CD40L may have a therapeutic impact on TED by downregulating the activation of CD40 on the surface of OFs ( + cells in CD4 + T, CD8 + T, and CD19 + B cells in the peripheral blood of patients with GD (101)
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Therefore, the establishment of a high-altitude hypobaric hypoxic reproductive system injury model is one of the key links in the research of plateau-related reproductive system diseases [4, 9]
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