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This implies that MTH1 may contribute to the heightened 8-oxoGsn levels in cardiomyocytes, thereby exacerbating damage to these cells ( 3.2 MTH1 role in neurological diseases Oxidative stress is a significant risk factor for Alzheimers disease (AD), with notable accumulation of 8-oxo-7,8-dihydroguanine (8-oxoG), an oxidized form of guanine, observed in AD brains

only one eighth of the sample received a true placebo, with three quarters of the multivitamin placebo group receiving combinations of vitamins A, C and E