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Review: hypoxia-inducible factor-1 (HIF-1): a novel transcription factor in immune reactions
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Conversely, when lactate is oxidized to pyruvate and enters mitochondrial oxidative pathways, it can indirectly elevate ROS production through electron leakage from the respiratory chain (87-89)

Some researchers may require higher doses or longer cycles to achieve noticeable effects, though increasing beyond standard protocols should be approached cautiously
