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When these defense mechanisms fail, the DNA damage response is activated, stopping the cell cycle for DNA repair [190]

IGF Binding Proteins and Bioavailability The mechanism underlying this enhanced potency relates to IGF-1's complex regulatory system involving IGF binding proteins (IGFBPs), a family of six high-affinity binding proteins (IGFBP-1 through IGFBP-6) that normally sequester the vast majority of circulating IGF-1 and regulate its bioavailability, half-life, and access to cell surface IGF-1 receptors