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There is large evidence that HGF can mediate neuroinflammation in the context of neurodegenerative autoimmune diseases such as multiple sclerosis (MS), leading to an indirect effect on the immune system

This observation is in line with (a) decreased plasma GSH levels in women who underwent surgical menopause (Kaur et al., 2017), and (b) decreased serum tGSH levels in post- relative to pre-menopausal women (Ramrez-Expsito et al., 2014)

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Indeed, persulfidation is evolutionarily conserved, and its levels are directly correlated with the organismal ability to fight oxidative stress (Zivanovic et al., 2019)