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Bladder hydrodistention, intratrigonal botulinum toxin A, neuromodulation, and extracorporeal shock wave therapies all may affect bladder symptoms based upon mechanisms of action that target local and/or distant nerve dysfunction, urothelial abnormalities, and others [22, 24, 25, 53,54,55,56,57,58] Myofascial Pelvic Floor Dysfunction Phenotype Myofascial pelvic floor dysfunction and/or tenderness may produce pain and urinary symptoms that are confusable with bladder-centric IC/BPS

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This treatment is especially helpful for older adults and those following a vegetarian or vegan diet with limited natural sources

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