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Technol Health Care 22(6):857865

Protective impact of L-carnitine against busulfan-induced male infertility: Following the significant growth of cancer incidence rate, the number of people undergoing chemotherapy is increasing

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Activation of aerobic glycolysis-related bypass pathways Increased glycolysis simultaneously activates multiple self-associated bypass pathways, among which the PPP provides the raw material for purine and pyrimidine nucleotide synthesis and maintains redox homeostasis for cancer cell growth, which largely depends on the activity of glucose-6-phosphate dehydrogenase (G6PD), as it catalyzes the first step of the glucose-6-phosphate shift to the PPP [46]