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The COG reported a very favorable prognosis (5-year EFS rate, 97% 1%) for patients with precursor B-cell phenotype, NCI standard risk age/leukocyte count, CNS1 status, and favorable cytogenetic abnormalities (either high hyperdiploidy with favorable trisomies or the ETV6 :: RUNX1 fusion) who had less than 0.01% MRD levels at both day 8 (from peripheral blood) and EOI (from bone marrow).[133] The excellent outcomes in patients with low MRD at the EOI were sustained for more than 10 years from diagnosis.[143] Modifying therapy on the basis of MRD determination has been shown to improve outcome

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[DOI] [PMC free article] [PubMed] [Google Scholar] 46.Pang Y, Zheng BY, Fan LW, Rhodes PG, Cai Z

doi: 10.1038/nature25486