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In other cases, the reactive forms of oxygen (singlet oxygen, the superoxide and hydroxyl radicals, hydrogen peroxide), that are not coped with by the natural detoxifying mechanisms, can react with biological structures and impair their physiological function
In addition, we demonstrated that NAC suppresses autophagy in RGCs of EAAC1 KO mice

Preincubation with copper sulfate increases its toxic effects on neurons (Sinopoli et al., 2014)

Kidney Disease: Patients with kidney disease should use B12 injections with caution, as the kidneys are involved in metabolizing B12
