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Although FOXO4 is present in a small fraction of normal cells, its expression is significantly increased in senescent cells 34

Baseline vitamin B12 levels before starting metformin Annual monitoring for patients on long-term metformin therapy Consideration of vitamin B12 supplementation if deficiency is detected Antibiotics and Chemotherapy Agents That Affect B12 Metabolism Certain antibiotics and chemotherapy agents can harm vitamin B12 metabolism

10.1523/JNEUROSCI.2948-09.2010 J
