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Human clinical-trial data (Phase 1/2 studies in wound healing, cardiac injury, and dry eye) exist only for a different, full-length recombinant thymosin beta-4 product, not for the short synthetic fragment marketed as TB-500, so no completed published human trial has evaluated TB-500 specifically for muscle, tendon, or joint recovery

Studies on rat testis presented that, in addition to spermatogenic cells, the quantity of supporting Sertoli and Leydig cells declined significantly in the rats exposed to busulfan in comparison with the control group

Metformin: historical overview

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